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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $33 | In Stock | |
5 mg | $51 | In Stock | |
10 mg | $81 | In Stock | |
25 mg | $153 | In Stock | |
50 mg | $252 | In Stock | |
100 mg | $342 | In Stock | |
500 mg | $827 | In Stock | |
1 mL x 10 mM (in DMSO) | $67 | In Stock |
Description | Epirubicin hydrochloride (Pharmorubicin) is an antineoplastic agent which can inhibit Topoisomerase. |
In vitro | At a dose of 3.5 mg/kg, Epirubicin demonstrated an inhibitory effect on human breast carcinoma xenograft R-27, suppressing tumor mass by 74.4%. Epirubicin exhibits clinical activity against a wide spectrum of tumors, including breast cancer, malignant lymphomas, soft tissue sarcomas, lung cancer, pleural mesothelioma, gastrointestinal cancer, head and neck cancer, ovarian cancer, prostate cancer, and transitional cell carcinoma of the bladder. |
In vivo | Epirubicin exhibits antitumor activity against a variety of cancer cells. At a concentration of 1.6 μg/mL, Epirubicin induces apoptosis in Hep G2 cells and enhances the activities of catalase, Se-dependent glutathione peroxidase, Cu, Zn-superoxide dismutase, and Mn-superoxide dismutase by 50%, 110%, 172%, and 135% respectively. Additionally, Epirubicin increases the expression of NADPH-CYP 450 reductase in cells while decreasing the expression of GST-π. |
Cell Research | Hep G2 cells (500 cells/well, monolayer) are plated in a 96-well plate. The next day the cells are treated with Epirubicin in the medium. At the end of the incubation periods, 15% volume of MTT dye solution is added. After 1 hr of incubation at 37℃, an equal volume of solubilization/stop solution (dimethylsul-foxide) is added to each well for an additional 1 hr incubation. The absorbance of the reaction solution at 570 nm is recorded.(Only for Reference) |
Alias | Pharmorubicin, 4'-epidoxorubicin HCl, Epirubicin HCl, 4'-Epidoxorubicin hydrochloride |
Molecular Weight | 579.98 |
Formula | C27H30ClNO11 |
Cas No. | 56390-09-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | 5% DMSO+95% Saline: 2.9 mg/mL (5 mM) DMSO: 42.86 mg/mL (73.89 mM) Ethanol: 5.8 mg/mL (10 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/5% DMSO+95% Saline
DMSO
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